A patient is suffering from ADA deficien | Class 12 Biology Chapter Biotechnology and its Application, Biotechnology and its Application NCERT Solutions

Adenosine deaminase deficiency is a metabolic disorder which causes immunodeficiency and damage to the immune system. It is caused by mutations in ADA gene. Approximately 10- 15 % of all cases of autosomal recessive forms of autosomal recessive forms of SCI among non- inbred population. SCID (Severe Combined Immuno Deficiency) disorder occurs due to adenosine deaminase deficiency. Adenosine deaminase catalyzes the conversion of adenosine to inosine, its deficiency results in accumulation of adenosine, and this interferes with purine metabolism that leads to the accumulation of nucleotides metabolites which are toxic to developing T- cell. This ADA deficiency can be present in infants, adolescence or in adults. It can be cured by bone marrow transplants (but by this deficiency cannot be permanently cured) or giving the approval of the germ line gene therapy which involves the permanent transmissible modifications of the genome of a gamete, a zygote or an embryo by this, deficiency can be permanently cured.